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British Journal of Nutrition - Abstract: Volume 94(3) September 2005 p 362-367 Insulin-like growth factor-1 and binding protein-3 in a 2-year soya intervention among premenopausal
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Insulin-like growth factor-1 and binding protein-3 in a 2-year
soya intervention among premenopausal women.

Full Paper
British Journal of Nutrition. 94(3):362-367, September 2005.
Maskarinec, Gertraud 1,*; Takata, Yumie 1; Murphy, Suzanne P. 1;
Franke, Adrian A. 1; Kaaks, Rudolph 2
Soya foods may protect against the development of breast cancer.
Insulin-like growth factor (IGF)-1 is under investigation as a
possible link between nutrition and cancer. We examined the effect
of soya foods on circulating IGF-1 and IGF binding protein (BP)-3
levels among 196 healthy premenopausal women in a 2-year
randomised nutritional trial. The intervention group consumed two
daily servings of soya foods including tofu, soya milk, soya nuts
and soya protein powder (equivalent to 50 mg isoflavones and 5-22
g soya protein per serving); the controls maintained their regular
diet. Five serum samples at baseline, 3, 6, 12, and 24 months were
collected in the morning during the luteal phase and analysed for
IGF-1 and IGFBP-3 by double-antibody ELISA. We applied mixed
models to investigate the intervention effect and predictors of
serum levels while considering the repeated measurement design.
Adherence with the study regimen was high and dropout rates were
acceptable. Randomisation resulted in similar mean IGF-1 and
IGFBP-3 levels by group. We did not observe a significant
intervention effect on IGF-1, IGFBP-3, and their molar ratio
during the entire study period. However, urinary isoflavone
excretion during the study period was positively associated with
IGF-1 (P = 0[middle dot]04) and the IGF-1:IGFBP-3 ratio (P =
0[middle dot]06). The effect was consistent over time. Adding soya
foods to the diet of premenopausal women does not appear to lower
serum levels of IGF-1 and IGFBP-3; if anything, the greater
protein intake from soya may lead to a small increase in IGF-1
serum levels.
Copyright(C) 2005 The Nutrition Society

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